{"id":3494,"date":"2016-03-16T16:26:32","date_gmt":"2016-03-16T14:26:32","guid":{"rendered":"http:\/\/www.genomed-biotech.com\/?post_type=portfolio&#038;p=3494"},"modified":"2016-03-30T09:18:27","modified_gmt":"2016-03-30T06:18:27","slug":"snp-detective-mefv-kit","status":"publish","type":"portfolio","link":"http:\/\/www.genomed-biotech.com\/index.php\/products\/snp-detective-mefv-kit\/","title":{"rendered":"SNP Detective MEFV Kit"},"content":{"rendered":"\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_image-f443215fcdacf9e2f4e485d3aab45d1c\">\n.avia-image-container.av-av_image-f443215fcdacf9e2f4e485d3aab45d1c img.avia_image{\nbox-shadow:none;\n}\n.avia-image-container.av-av_image-f443215fcdacf9e2f4e485d3aab45d1c .av-image-caption-overlay-center{\ncolor:#ffffff;\n}\n<\/style>\n<div  class='avia-image-container av-av_image-f443215fcdacf9e2f4e485d3aab45d1c av-styling- avia-align-center  avia-builder-el-0  el_before_av_two_third  avia-builder-el-first '   itemprop=\"image\" itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/ImageObject\" ><div class=\"avia-image-container-inner\"><div class=\"avia-image-overlay-wrap\"><img decoding=\"async\" fetchpriority=\"high\" class='wp-image-3480 avia-img-lazy-loading-not-3480 avia_image ' src=\"http:\/\/www.genomed-biotech.com\/wp-content\/uploads\/2016\/03\/mefv-o-cc-88n-1500x630.jpg\" alt='' title='mefv o\u0308n'  height=\"630\" width=\"1500\"  itemprop=\"thumbnailUrl\"  \/><\/div><\/div><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_two_third-9497bbf8bff73ea4c6992cc17fa9ec36\">\n.flex_column.av-av_two_third-9497bbf8bff73ea4c6992cc17fa9ec36{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-av_two_third-9497bbf8bff73ea4c6992cc17fa9ec36 av_two_third  avia-builder-el-1  el_after_av_image  el_before_av_one_third  first flex_column_div av-zero-column-padding  '     ><section  class='av_textblock_section av-av_textblock-0366cc7376be6c9e82a3e9cc8987b64f '   itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class='avia_textblock'  itemprop=\"text\" ><p style=\"text-align: justify;\">The MEFV (Mediterranean fever) gene provides instructions for making a protein called pyrin assists in keeping the inflammation process under control. Inflammation occurs when the immune system sends signaling molecules and white blood cells to a site of injury or disease to fight microbial invaders and facilitate tissue repair. When this has been accomplished, the body stops the inflammatory response to prevent damage to its own cells and tissues.<\/p>\n<p style=\"text-align: justify;\">More than 80 MEFV gene mutations that cause familial Mediterranean fever have been identified. Rare mutations cause small base deletions in the MEFV gene, which can lead to an abnormally small, nonfunctional protein. Most MEFV gene mutations, however, alter one of the amino acids used to make pyrin. MEFV gene mutations lead to reduced amounts of pyrin or a malformed pyrin protein that cannot function properly. As a result, pyrin cannot perform its presumed role in controlling inflammation, leading to an inappropriate or prolonged inflammatory response. Fever and inflammation in the abdomen, chest, joints, or skin are signs of familial Mediterranean fever.<\/p>\n<\/div><\/section><br \/>\n<div  class='tabcontainer av-av_tab_container-0bacd910096d11a3cec6dfb538798966 top_tab  avia-builder-el-3  el_after_av_textblock  avia-builder-el-last '>\n<section class='av_tab_section av_tab_section av-av_tab-618106d451774598763fabd963d4a3bc'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div id='tab-id-1-tab' class='tab active_tab' role='tab' aria-selected=\"true\" tabindex=\"0\" data-fake-id='#tab-id-1' aria-controls='tab-id-1-content'  itemprop=\"headline\" >Product Overview<\/div><div id='tab-id-1-content' class='tab_content active_tab_content' role='tabpanel' aria-labelledby='tab-id-1-tab' aria-hidden=\"false\"><div class='tab_inner_content invers-color'  itemprop=\"text\" ><p style=\"text-align: justify;\">SNP DETECTIVE MEFV kit contains 4 primer pairs for amplification of exon 2-3-5-10 of the MEFV gene. 18 region-specific probes and 37 single-base-specific fluorescence labelled DNA probes are used for detection of SNPs (Single Nucleotide Polymorphisms). The kit uses a five-dye fluorescent system which allows multiplex amplification-ligation in the same tube for automated SNP analysis. The SNP Detective MEFV Kit incorporates an external control with a wild-type pattern for all related mutations to ensure the performance of the ligation reagents and to investigate troubleshooting related with genomic DNA and DNA probes.<\/p>\n<p style=\"text-align: justify;\"><a href=\"http:\/\/www.genomed-biotech.com\/wp-content\/uploads\/2016\/03\/mefv.png\" rel=\"attachment wp-att-3483\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-gallery wp-image-3483\" src=\"http:\/\/www.genomed-biotech.com\/wp-content\/uploads\/2016\/03\/mefv-845x684.png\" alt=\"mefv\" width=\"845\" height=\"684\" srcset=\"http:\/\/www.genomed-biotech.com\/wp-content\/uploads\/2016\/03\/mefv-845x684.png 845w, http:\/\/www.genomed-biotech.com\/wp-content\/uploads\/2016\/03\/mefv-495x400.png 495w\" sizes=\"auto, (max-width: 845px) 100vw, 845px\" \/><\/a><\/p>\n<\/div><\/div><\/section>\n<section class='av_tab_section av_tab_section av-av_tab-ea482c7b183abe2dbbf8fbb01da3aaa4'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div id='tab-id-2-tab' class='tab' role='tab' aria-selected=\"false\" tabindex=\"0\" data-fake-id='#tab-id-2' aria-controls='tab-id-2-content'  itemprop=\"headline\" >Region of Interest<\/div><div id='tab-id-2-content' class='tab_content' role='tabpanel' aria-labelledby='tab-id-2-tab' aria-hidden=\"true\"><div class='tab_inner_content invers-color'  itemprop=\"text\" ><table width=\"575\">\n<tbody>\n<tr>\n<td><strong>Location in the Gene<\/strong><\/td>\n<td><strong>Amino Acid Change<\/strong><\/td>\n<td><strong>Sequence Change<\/strong><\/td>\n<\/tr>\n<tr>\n<td rowspan=\"4\">Exon-2<\/td>\n<td><strong>E148Q<\/strong><\/td>\n<td>c.442G&gt;C<\/td>\n<\/tr>\n<tr>\n<td><strong>E167D<\/strong><\/td>\n<td><em>c<\/em>.501A&gt;T<\/td>\n<\/tr>\n<tr>\n<td><strong>R202Q<\/strong><\/td>\n<td><em>c<\/em>.605G&gt;A<\/td>\n<\/tr>\n<tr>\n<td><strong>S179I<\/strong><\/td>\n<td><em>c<\/em>.536G&gt;T<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\">Exon-3<\/td>\n<td><strong>P369S<\/strong><\/td>\n<td>c.1105C&gt;T<\/td>\n<\/tr>\n<tr>\n<td><strong>P350R<\/strong><\/td>\n<td><em>c<\/em>.1049C&gt;G<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"2\">Exon-5<\/td>\n<td><strong>Y471X<\/strong><\/td>\n<td><em>c<\/em>.1413C&gt;A<\/td>\n<\/tr>\n<tr>\n<td><strong>F479L<\/strong><\/td>\n<td>c.1437C&gt;G<\/td>\n<\/tr>\n<tr>\n<td rowspan=\"10\">Exon-10<\/td>\n<td><strong>M694V<\/strong><\/td>\n<td>c.2080A&gt;G<\/td>\n<\/tr>\n<tr>\n<td><strong>R761H<\/strong><\/td>\n<td>c.2282G&gt;A<\/td>\n<\/tr>\n<tr>\n<td><strong>A744S<\/strong><\/td>\n<td>c.2230G&gt;T<\/td>\n<\/tr>\n<tr>\n<td><strong>M680I<\/strong><\/td>\n<td><em>c<\/em>.2040G&gt;C +<em> c<\/em>.2040G&gt;A<\/td>\n<\/tr>\n<tr>\n<td><strong>G632A<\/strong><\/td>\n<td><em>c<\/em>.1895G&gt;C<\/td>\n<\/tr>\n<tr>\n<td><strong>V726A<\/strong><\/td>\n<td>c.2177T&gt;C<\/td>\n<\/tr>\n<tr>\n<td><strong>K695R<\/strong><\/td>\n<td>c.2084A&gt;G<\/td>\n<\/tr>\n<tr>\n<td><strong>K695N<\/strong><\/td>\n<td>c.2085G&gt;C<\/td>\n<\/tr>\n<tr>\n<td><strong>M694I<\/strong><\/td>\n<td>c.2082G&gt;A<\/td>\n<\/tr>\n<tr>\n<td><strong>I692del<\/strong><\/td>\n<td>c.2076_2078del<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><\/div><\/section>\n<section class='av_tab_section av_tab_section av-av_tab-e9d41cb7a1df35f8a2a6e2d96ed1eeb2'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div id='tab-id-3-tab' class='tab' role='tab' aria-selected=\"false\" tabindex=\"0\" data-fake-id='#tab-id-3' aria-controls='tab-id-3-content'  itemprop=\"headline\" >Main Features<\/div><div id='tab-id-3-content' class='tab_content' role='tabpanel' aria-labelledby='tab-id-3-tab' aria-hidden=\"true\"><div class='tab_inner_content invers-color'  itemprop=\"text\" ><ul>\n<li>Advances in capillary electrophoresis platforms and five-dye technology provide high precision and easy analysis.<\/li>\n<li>Precise and quick genotyping for all mutations in the same plot screen.<\/li>\n<li>Multiple samples can be analyzed in seconds, using GeneMapper<sup>\u00ae<\/sup> or GeneMarker Software.<\/li>\n<li>Accurate and quick results<\/li>\n<li>Minimal material and chemical consumption<\/li>\n<\/ul>\n<\/div><\/div><\/section>\n<section class='av_tab_section av_tab_section av-av_tab-ea1c6b29a588693cb336629ac3f00720'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div id='tab-id-4-tab' class='tab' role='tab' aria-selected=\"false\" tabindex=\"0\" data-fake-id='#tab-id-4' aria-controls='tab-id-4-content'  itemprop=\"headline\" >Order Information<\/div><div id='tab-id-4-content' class='tab_content' role='tabpanel' aria-labelledby='tab-id-4-tab' aria-hidden=\"true\"><div class='tab_inner_content invers-color'  itemprop=\"text\" ><table class=\"avia-table avia-data-table avia-table-4 avia-builder-el-12 el_after_av_table avia-builder-el-last \">\n<tbody>\n<tr class=\"avia-heading-row\">\n<th class=\"\">Cat. No<\/th>\n<th class=\"\">Description<\/th>\n<\/tr>\n<tr class=\"\">\n<td class=\"\">201100<\/td>\n<td class=\"\">100 tests<\/td>\n<\/tr>\n<tr class=\"\">\n<td class=\"\">201050<\/td>\n<td class=\"\">50 tests<\/td>\n<\/tr>\n<tr class=\"\">\n<td class=\"\">201025<\/td>\n<td class=\"\">25 tests<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div><\/div><\/section>\n<section class='av_tab_section av_tab_section av-av_tab-65d033b3e2bbecbbcd984a41b2018c77'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div id='tab-id-5-tab' class='tab' role='tab' aria-selected=\"false\" tabindex=\"0\" data-fake-id='#tab-id-5' aria-controls='tab-id-5-content'  itemprop=\"headline\" >Product Support<\/div><div id='tab-id-5-content' class='tab_content' role='tabpanel' aria-labelledby='tab-id-5-tab' aria-hidden=\"true\"><div class='tab_inner_content invers-color'  itemprop=\"text\" ><p>Please email us for product support requests\u00a0and include your product LOT number.<\/p>\n<p>Support e-mail:\u00a0<a href=\"mailto:support@genomed-biotech.com\">support@genomed-biotech.com<\/a><\/p>\n<\/div><\/div><\/section>\n<\/div><\/p><\/div>\n\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_one_third-9c1d454dc06f7247226bc4e8f931daae\">\n.flex_column.av-av_one_third-9c1d454dc06f7247226bc4e8f931daae{\nborder-radius:0px 0px 0px 0px;\npadding:0px 0px 0px 0px;\n}\n<\/style>\n<div  class='flex_column av-av_one_third-9c1d454dc06f7247226bc4e8f931daae av_one_third  avia-builder-el-4  el_after_av_two_third  avia-builder-el-last  flex_column_div av-zero-column-padding  '     ><p>\n<style type=\"text\/css\" data-created_by=\"avia_inline_auto\" id=\"style-css-av-av_hr-c9ba6ccf0e28539cef079a4b419f7f68\">\n#top .hr.hr-invisible.av-av_hr-c9ba6ccf0e28539cef079a4b419f7f68{\nheight:25px;\n}\n<\/style>\n<div  class='hr av-av_hr-c9ba6ccf0e28539cef079a4b419f7f68 hr-invisible  avia-builder-el-5  el_before_av_icon_box  avia-builder-el-first '><span class='hr-inner '><span class=\"hr-inner-style\"><\/span><\/span><\/div><br \/>\n<article  class='iconbox iconbox_top av-av_icon_box-b3da16b9f1f82d31cd88ccd7d0ab6ac7  avia-builder-el-6  el_after_av_hr  el_before_av_icon_box  main_color'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class=\"iconbox_content\"><header class=\"entry-content-header\" aria-label=\"Icon: Genomic DNA Extraction\"><div class=\"iconbox_icon heading-color\" aria-hidden='true' data-av_icon='\ue89a' data-av_iconfont='entypo-fontello'><\/div><h3 class='iconbox_content_title '  itemprop=\"headline\" >Genomic DNA Extraction<\/h3><\/header><div class='iconbox_content_container '  itemprop=\"text\" ><\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><br \/>\n<article  class='iconbox iconbox_top av-av_icon_box-cd92413b108e1bcad940088af8dae27f  avia-builder-el-7  el_after_av_icon_box  el_before_av_icon_box  main_color'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class=\"iconbox_content\"><header class=\"entry-content-header\" aria-label=\"Icon: Multiplex PCR Amplification\"><div class=\"iconbox_icon heading-color\" aria-hidden='true' data-av_icon='\ue887' data-av_iconfont='entypo-fontello'><\/div><h3 class='iconbox_content_title '  itemprop=\"headline\" >Multiplex PCR Amplification<\/h3><\/header><div class='iconbox_content_container '  itemprop=\"text\" ><\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><br \/>\n<article  class='iconbox iconbox_top av-av_icon_box-1a1de85323f74a57586285ab79587c62  avia-builder-el-8  el_after_av_icon_box  el_before_av_icon_box  main_color'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class=\"iconbox_content\"><header class=\"entry-content-header\" aria-label=\"Icon: Probe Ligation Reaction\"><div class=\"iconbox_icon heading-color\" aria-hidden='true' data-av_icon='\ue887' data-av_iconfont='entypo-fontello'><\/div><h3 class='iconbox_content_title '  itemprop=\"headline\" >Probe Ligation Reaction<\/h3><\/header><div class='iconbox_content_container '  itemprop=\"text\" ><\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><br \/>\n<article  class='iconbox iconbox_top av-av_icon_box-979ac548b3ffe0f2eedc250f7be3daed  avia-builder-el-9  el_after_av_icon_box  el_before_av_icon_box  main_color'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class=\"iconbox_content\"><header class=\"entry-content-header\" aria-label=\"Icon: Capillary Electrophoresis\"><div class=\"iconbox_icon heading-color\" aria-hidden='true' data-av_icon='\ue887' data-av_iconfont='entypo-fontello'><\/div><h3 class='iconbox_content_title '  itemprop=\"headline\" >Capillary Electrophoresis<\/h3><\/header><div class='iconbox_content_container '  itemprop=\"text\" ><\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><br \/>\n<article  class='iconbox iconbox_top av-av_icon_box-4387a97f0b3b3a137a4ac2af6c14a6b2  avia-builder-el-10  el_after_av_icon_box  avia-builder-el-last  main_color'  itemscope=\"itemscope\" itemtype=\"https:\/\/schema.org\/CreativeWork\" ><div class=\"iconbox_content\"><header class=\"entry-content-header\" aria-label=\"Icon: Data Analysis\"><div class=\"iconbox_icon heading-color\" aria-hidden='true' data-av_icon='\ue887' data-av_iconfont='entypo-fontello'><\/div><h3 class='iconbox_content_title '  itemprop=\"headline\" >Data Analysis<\/h3><\/header><div class='iconbox_content_container '  itemprop=\"text\" ><\/div><\/div><footer class=\"entry-footer\"><\/footer><\/article><\/p><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":3480,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"tags":[],"portfolio_entries":[34],"class_list":["post-3494","portfolio","type-portfolio","status-publish","has-post-thumbnail","hentry","portfolio_entries-diagnostic-kits"],"_links":{"self":[{"href":"http:\/\/www.genomed-biotech.com\/index.php\/wp-json\/wp\/v2\/portfolio\/3494","targetHints":{"allow":["GET"]}}],"collection":[{"href":"http:\/\/www.genomed-biotech.com\/index.php\/wp-json\/wp\/v2\/portfolio"}],"about":[{"href":"http:\/\/www.genomed-biotech.com\/index.php\/wp-json\/wp\/v2\/types\/portfolio"}],"author":[{"embeddable":true,"href":"http:\/\/www.genomed-biotech.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/www.genomed-biotech.com\/index.php\/wp-json\/wp\/v2\/comments?post=3494"}],"version-history":[{"count":1,"href":"http:\/\/www.genomed-biotech.com\/index.php\/wp-json\/wp\/v2\/portfolio\/3494\/revisions"}],"predecessor-version":[{"id":3506,"href":"http:\/\/www.genomed-biotech.com\/index.php\/wp-json\/wp\/v2\/portfolio\/3494\/revisions\/3506"}],"wp:featuredmedia":[{"embeddable":true,"href":"http:\/\/www.genomed-biotech.com\/index.php\/wp-json\/wp\/v2\/media\/3480"}],"wp:attachment":[{"href":"http:\/\/www.genomed-biotech.com\/index.php\/wp-json\/wp\/v2\/media?parent=3494"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/www.genomed-biotech.com\/index.php\/wp-json\/wp\/v2\/tags?post=3494"},{"taxonomy":"portfolio_entries","embeddable":true,"href":"http:\/\/www.genomed-biotech.com\/index.php\/wp-json\/wp\/v2\/portfolio_entries?post=3494"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}